Like many innovative aesthetic treatments, Rejuran was developed in South Korea and represents a modern approach to skin rejuvenation. Rather than simply masking signs of aging, it focuses on restoring skin health from within by stimulating the skin’s own regenerative processes. The treatment helps improve elasticity and hydration while gradually restoring a more youthful appearance.
Rejuran works directly on skin cells, stimulating regeneration and supporting collagen production. After treatment, the skin appears firmer, brighter, and more resilient to external stressors.
Who Is Rejuran Suitable For?
Rejuran is suitable both as a preventative treatment for younger skin beginning to show early signs of aging and as intensive regeneration for mature skin with visible wrinkles and a tired appearance.
We use it around the eye area to address:
- loss of skin elasticity and firmness
- fine to moderate wrinkles
- dehydrated and fatigued skin
Rejuran is also used to improve the appearance of scars, including: post-acne scarring, ideally combined with Morpheus8 and scars resulting from injuries or surgery.
What Is Rejuran and How Does It Work?
Rejuran contains polynucleotides — biologically active molecules derived from salmon DNA. These substances are highly biocompatible with human skin and are known for their powerful regenerative and healing properties.
This is not an injection of “foreign cells.” Polynucleotides are DNA fragments that act as a biostimulatory signal, activating the skin’s own natural regenerative processes.
Once injected into the skin, they stimulate fibroblasts — the cells responsible for producing collagen, elastin, and hyaluronic acid, all of which are essential for firmness, elasticity, and hydration. As we age, fibroblast activity naturally declines, but Rejuran helps reactivate these cells and restore their regenerative function. The result is healthier, firmer, and more radiant-looking skin.
Unlike dermal fillers, Rejuran does not add volume or alter facial contours — it works by improving skin quality itself. The results are subtle, natural-looking, and long-lasting.
How Long Do Rejuran Results Last?
Initial improvements gradually become visible over several weeks as the skin regeneration process develops, typically after the second or third treatment session. The best results are achieved with a treatment series — usually three sessions spaced three weeks apart, followed by maintenance treatments every 3–6 months.
Results generally last around 6–12 months. To maintain the effect, regular maintenance treatments are recommended.
I want to rejuvenate my skin with Rejuran.
How Is Rejuran Applied?
Rejuran is administered through a series of fine microinjections. Before the procedure, the treated area is numbed with a topical anesthetic cream to ensure maximum comfort. Immediately after the treatment, small swollen and slightly red bumps may appear at the injection sites. These reactions are temporary and typically subside within a few hours to a few days.
What Is the Difference Between Mesotherapy and Rejuran?
At first glance, mesotherapy and Rejuran may seem similar — both are injectable treatments designed to improve skin quality while maintaining a natural-looking result. The key difference lies in the way they work within the skin.
- Mesotherapy: Delivering Nutrients – Mesotherapy works by delivering active ingredients directly into the skin. The formulations typically contain a balanced combination of hyaluronic acid, vitamins, amino acids, and antioxidants. Once the skin receives intensive hydration and nourishment, it appears smoother, firmer, and healthier both visually and to the touch.
- Rejuran: Regeneration From Within – Rejuran does not work as a “nutrient boost,” but rather as a form of biostimulation — teaching the skin to function optimally again. Polynucleotides activate fibroblasts, restoring collagen and elastin production and gradually improving the skin’s internal structure. Over time, firmness and elasticity improve, damaged cells regenerate, and the skin naturally rejuvenates itself.
Based on your skin condition and desired results, your physician will recommend the treatment best suited to your needs.
Watch the video of the treatment.
- Avoid sun exposure and excessive heat for several days after the procedure.
- Do not touch the treated area excessively for a few hours after the treatment.
- Makeup should ideally be avoided for 24 hours. If necessary, use a completely new product to reduce the risk of infection.
- Avoid skincare products containing vitamin C, retinol, and exfoliating or brightening acids for 2–3 days.
- For 1–2 days, avoid intense physical activity, sauna, cryotherapy, or tanning beds. Be gentle when cleansing or touching the face.
- Avoid cosmetic massages and laser treatments for 2 weeks after the procedure
- Avoid alcohol for at least 24 hours before and after treatment, as it can dilate blood vessels and increase the risk of bruising and swelling in the treated area.
- Before the procedure, your physician will review all instructions with you once again.
Pregnancy or breastfeeding, hypersensitivity to any of the ingredients in the product, and any ongoing infectious disease (including everything from a mild cold to active cold sores or canker sores).
FAQ – Frequently Asked Questions About Rejuran
After the procedure, the skin may appear slightly red and small swollen injection marks can occur. These reactions usually subside within a few hours, or within 1–3 days at most.
We recommend a treatment series consisting of three sessions spaced three weeks apart, followed by a maintenance treatment every 3–6 months.
Both procedures work in a similarly gentle and natural way — they do not alter facial contours or features and are administered through injections. Generally speaking, mesotherapy is ideal if you are looking for quick hydration, refreshment, and a radiant boost for tired skin. Rejuran is more suitable for concerns related to skin quality, loss of firmness, and fine lines. Our physicians will assess your skin and expectations to recommend the most appropriate treatment.
Yes. Rejuran can be combined with treatments such as botulinum toxin or laser procedures (for example V-Beam laser rejuvenation). Our physicians can create a comprehensive treatment plan tailored specifically to your skin’s needs.
Rejuran is safe and very well tolerated. It is suitable for anyone looking to improve overall skin quality, regardless of age. It works well both as prevention and as a treatment for already visible signs of aging.
Usually yes, but with caution. Rejuran contains only purified polynucleotides — DNA fragments completely purified from cellular structures — so they are not considered the same as fish proteins themselves. Nevertheless, it is important to inform your physician in advance and, if necessary, perform a tolerance test before treatment.
| Rejuran Skin Biostimulation | Price |
|---|---|
| Initial examination (paid only on the 1st visit) | 500 CZK |
| Rejuran I (eye area) | 8 200 CZK |
| Rejuran S (scars) | 8 200 CZK |
